Research news: Brain Pathway Responsible For Obesity Found: Too Many Calories Send Brain Off Kilter

The News:
Brain Pathway Responsible For Obesity Found: Too Many Calories Send Brain Off Kilter
ScienceDaily (Oct. 3, 2008) — An overload of calories throws critical portions of the brain out of whack, reveals a study in the October 3rd issue of the journal Cell, a Cell Press publication. That response in the brain's hypothalamus—the "headquarters" for maintaining energy balance—can happen even in the absence of any weight gain, according to the new studies in mice.
The brain response involves a molecular player, called IKKß/NF-κB, which is known to drive metabolic inflammation in other body tissues. The discovery suggests that treatments designed to block this pathway in the brain might fight the ever-increasing spread of obesity and related diseases, including diabetes and heart disease.
"This pathway is usually present but inactive in the brain," said Dongsheng Cai of the University of Wisconsin-Madison. Cai said he isn't sure exactly why IKKß/NF-κB is there and ready to spring into action in the brain. He speculates it may have been an important element for innate immunity, the body's first line of defense against pathogenic invaders, at some time in the distant past. Read on..

The Research:
Read the research behind this story in the journal Cell.